As we knew,the past research showed that acupuncture has an antioxidant effect in the treatment of Parkinsonís disease. Mounting evidence shows that oxidative stress contributes to the progression of Parkinsonís disease. The that research showed that 100 Hz electroacupuncture applied to acupuncture points St36 (ZuSanLi) and Sp6 (SanYinJiao) has a neuroprotective effect on the brain because electroacupuncture is antioxidant. But,the direct effects of electro-acupuncture (EA) on the dopaminergic neurotransmitter system in Parkinson's disease (PD) patients remain elusive.
More than a million North Americans also have the neurological disease (it disrupts production of the neurotransmitter dopamine, which can affect movement, balance, thinking and emotions). It can take 20 years for the characteristic spasms and twitches to develop. The first signs -- often ignored -- include loss of sense of smell and jerky movements during deep sleep. The latest theory about the cause: a virus that enters the body through the nose or gut. Contaminated, illicit designer drugs also have been known to trigger the disorder.
While there is no cure as of now, some alternative therapies (used along with conventional medications) seem to ease symptoms. The latest news is that acupuncture, when used on a specific point (GB34) on the outside of the right leg below the knee, reactivates, at least temporarily, an area of the brain that is knocked offline by Parkinson's. So far, we haven't seen any negative side effects.
To more understand this,Chinese 1st Affiliated Hospital of Xi'an Jiao Tong University has done research about this.In their present study, 0, 2 or 100Hz EA was applied to acupoints Sanyinjiao (SP6), Yanglingquan (GB34) and Zusanli (ST36) in a rat model unilaterally lesioned by 6-hydroxydopamine. Rotational behavior tests were performed and the animals were then decapitated. Levels of striatal dopamine (DA), dopamine transporter, and D1- and D2-like DA receptors were subsequently evaluated.
Chinese researchers found that high-frequency EA might work by acting on presynaptic dopamine transporter and postsynaptic dopamine receptors simultaneously to achieve a therapeutic effect in PD patients and models. This might shed some light on the mechanism by which EA affects the DA neurotransmitter system.
Copyright © 2012. Published by Elsevier B.V.
Reference:Rui G, Guangjian Z, Yong W, Jie F, Yanchao C, Xi J, Fen L. Behav Brain Res. 2012 Oct 1. pii: S0166-4328(12)00633-X. doi: 10.1016/j.bbr.2012.09.047
A 56-year-old man diagnosed in 2003 as having Hoehn & Yahr stage III Parkinson's disease (PD) came to our clinic in 2012 with slurred speech, right-sided bradykinesia, erectile dysfunction, rigidity, emotional instability and depression. His PD showed progressive signs with postural instability, moderate bilateral signs, and he rated 80% on the Schwab & England Activities of Daily Living Scale. A modified protocol of electroacupuncture was administered for a period of 5 weeks, six times per week, with each session lasting for 30 min. Assessments were based on the Berg Balance Scale (BBS) and Parkinson's Disease Questionnaire-39 (PDQ-39) items, a disease-specific measure of subjective health status. He showed improvement on the BBS, suggesting improved functional status. His quality of life showed improvement particularly on the 'activities of daily living', 'cognition' and 'communication' dimensions of the PDQ-39. Acupuncture treatments in animal experiments have generated valuable mechanistic insights that could be relevant to PD, for example, demonstrating its neuroprotective potential from stimulation of various neuroprotective agents. The literature also suggests acupuncture may play a role in the improvement of motor function and quality of life in PD. Acupuncture is tolerated well by individuals with PD and should be considered as an integrative approach for their symptomatic